When picking or editing a gaming or anime PFP, focus on a strong silhouette and...

https://zandersnicecolumns.inkharbory.com/posts/why-do-bold-cartoon-faces-read-better-than-realistic-art-in-tiny-icons

When picking or editing a gaming or anime PFP, focus on a strong silhouette and high contrast to keep it clear at small sizes. Crop the face close for better recognition, and use a simple background to avoid distractions